Histamine and sex organs

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Dr Janice Joneja, a world expert on histamine intolerance, has published two books on histamine intolerance:. A Beginner's Guide to Histamine Intolerance — read more about it here. Buy the paperback from Amazon here; buy the e-book from Amazon here.

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Undeniably, histamine HA is a biogenic amine with great significance in medicine and biology. In particular, the literature on the relation between HA and male reproduction has greatly expanded over the past years, resulting in the identification of novel functions for HA within the male reproductive system of several species, including human. This review summarizes what is presently known regarding the effects of HA on the different cell types of the testis, with special focus on Leydig cells.

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Histamine HA is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase HDC in most mammalian tissues. The literature on the role of HA within the male gonad has expanded over the last years, attracting attention to potential unexpected side-effects of anti-histamines on testicular function. It should then be considered that anti-histamines may affect testicular homeostasis by increasing or decreasing steroid production.

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Histamine was found to be present in the testes, seminal vesicles and prostate glands of the mouse, rat and rabbit. Sex accessory organs contained much higher concentrations of histamine than did testicular tissue. Testosterone propionate administration prevented the increase in histamine concentration and content normally seen in the castrate rat. Results from these studies suggest that previously described sex differences in histamine metabolism, at least in the rat, may be related to sex accessory tissue.

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Histamine is a chemical, known as a biogenic amine. The body gets all the histamine it needs from its own cells, but histamine is also found in certain foods. People who experience an allergy-like response to histamine-rich foods may have a condition known as histamine intolerance.

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Histamine is an organic nitrogenous compound involved in local immune responsesas well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Histamine increases the permeability of the capillaries to white blood cells and some proteinsto allow them to engage pathogens in the infected tissues. In aqueous solutionthe imidazole ring of histamine exists in two tautomeric forms, identified by which of the two nitrogen atoms is protonated.

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Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity.

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Researchers publishing in Reproduction examine the association between antihistamines and the potential consequences for male fertility. An impact on male fertility is not a known side effect of antihistamines, however we will keep any new evidence under review. However, I think the evidence is really too limited to say whether anti-histamine medication does or does not have a detrimental impact on male fertility.

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Histamine isolated from many different tissues, acts via three types of histamine receptors: H1, H2 and H3. In peripheral tissues histamine is mainly stored in mast cells MC. Presence of mast cells was proved also in mammals' uteri.

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