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Solid cancers are dependent on angiogenesis for sustenance. The FDA approval of Bevacizumab in inspired many scientists to develop more inhibitors of angiogenesis. Although several monoclonal antibodies mAbs are being administered to successfully combat various pathologies, the complexity and large size of mAbs seem to narrow the therapeutic applications.

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The precursor homocysteine is metabolized either through the methionine cycle to produce methionine or through the transsulfuration pathway to synthesize cysteine. Alternatively, cysteine can be obtained through uptake of its oxidized form, cystine. Many cancer cells exhibit methionine dependency such that their proliferation is impaired in growth media in which methionine is replaced by homocysteine. Here, we showed that oncogenic PIK3CA and decreased expression of SLC7A11a gene that encodes a cystine transporter also known as xCT, correlated with increased methionine dependency in breast cancer cells.

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Toggle navigation Radiology Imaging. Webb Medical Center Del E. Medical Ctr.

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The heparan sulfate proteoglycan syndecan-1 Sdc1 modulates cell proliferation, adhesion, migration and angiogenesis. Proteinase-mediated shedding converts Sdc1 from a membrane-bound coreceptor into a soluble effector capable of binding the same ligands. In breast carcinomas, Sdc1 overexpression correlates with poor prognosis and an aggressive phenotype.

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These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online.

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Palmer Cooper and David E. Huffington Post May 12, Nixon Redux? And will they ever see the light of day?

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FoxValleyWIStrides cancer. But at the same time, we can all do something about it. Check out the amazing and inspiring photos. It's almost time to walk together and make a bigger impact on breast cancer.

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